Actually, picking a good domain name is based on you are going to put in there. You might be planning to set up an online pizza delivery or something, so you have to pick a domain name which is related to pizza or pizza delivery. There is a lot of domain names available, you just have to be creative.
Sometimes what you are looking for is not available, it happens. So strategy comes in to action, go to your dreamed website and made a nice offer to buy the domain name. But what is most important are the content. If you have a nice set up, chances are, you will succeed.